Synthesis of New Gemcitabine Derivatives Linked Tetrazole Ring as Antibacterial Activity

A series of novel tetrazole derivatives contain nucleoside analog were synthesized by reaction between azido gemcitabine with nitrile compounds in presence ammonium chloride as catalyst. The structures of all prepared compounds were analyzed by NMR and FTIR spectroscopic methods. The antibacterial activity of tetrazole derivatives were determined by using Streptococcus Pneumonia and Escherichia Coli, Staphylococcus aureus.