Activity of Monooxygenase and Nitrogenous Systems in Liver Microsomes Under the Influence of Inducers and Inhibitors of Medicinal Metabolism on the Organism in Conditions of Liver Pathology

In experiments on 48 white-breed rats of males with a mass of 180-250 g. it was found that benzonal in an effective dose of 75 mg/kg had a favorable effect on the monoxygenase and nitration system of hepatocyte microcircuits of rats with acute liver damage, while cimetidine in a dose of 10 mg/kg further suppressed the activity of MCO, increased the formation of toxic radicals NO, leading to an even greater aggravation of the severity of the animals.