Topical Gel Formulation to Manage Peripheral Neuropathy Induced By Chemotherapy

1Jitender Madan, Upendra Kumar Jain

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Abstract:

PN is a chronic disease of symmetric distal damage to peripheral nerves caused by many forms of medicine and chemotherapy agent. Peripheral neuropathy is a dangerous disorder. Peripheral neuropathy (CIPN) caused by chemotherapy is an side outcome estimated to be present in 40% of chemotherapy patients, with an elevated frequency of single agent therapies in cancer. In treating and avoiding CIPN, pharmacists play a significant role by the prescription of validated pharmacological and non-pharmacological approaches ideal for each individual. CIPN symptoms usually originate with the hands, feet and stretch out into the arms and legs. Commonly reported sensory symptoms are hyperalgesia, paresthesia, hypoalgesia, dysthesia, burning, allodynia, electric and shock like sensations. Several therapeutic agents have been evaluated for symptomatic treatment of CIPN, which includes serotonin-norepinephrine reuptake inhibitors (duloxetine), anticonvulsants (pregabalin and gabapentin) and analgesics include some opioids and NSAIDS. Currently most of the treatments available in the market are orally administered. Due to oral administration, these drugs exhibit large number of intolerable systemic side effects. The aim of this study is to provide a dosage form that does not interfere with the activity of chemotherapeutic drugs in cancer patients, as the route of drug delivery is topical for treatment of neuropathy

Keywords:

Peripheral neuropathy, chemotherapy, NSAID, pharmacological, analgesics, topical

Paper Details
Month12
Year2019
Volume24
IssueIssue 6
Pages213-230