OMEGA FATTY ACIDS IN HEALTH AND DISEASED STATE - A REVIEW
DOI:
https://doi.org/10.61841/r6pmhh85Keywords:
Omega-3 fatty acids, Cardiovascular disease4, Coronary Heart Disease, Atherosclerosis.Abstract
The dietary lipids have a significant job in tweaking the onset of autoimmunity, cardiovascular diseases and cancer. Several studies have been led to build up the adverse impacts of saturated fats in humans and animals. The intake of oils containing both monounsaturated omega-9 and polyunsaturated fats in essentially emerging over certain nations. Yet, the increased uptake of certain vegetable oils of ω-6 series is anyway to be seen as proinflammatory and it is one of the potential causes for the steady ascent in some malignant tumors, rheumatoid arthritis and autoimmune disease that are basically caused because of the increased production of proinflammatory cytokines. Diets dependent on ω-6 enhanced oils can elevate the level of linolenic acid in tissue phosphoglycerides and can lessen cholesterol levels. Yet these lipids tend to increase unnecessary rise of arachidonic acids. In contrast, ω-3 fatty acids-enriched fish oils or omega-3 precursors from certain vegetable oils are found to give protection against cardiovascular disease, rheumatoid arthritis, cancer and against the seriousness of some viral diseases.
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References
1. Gillies PJ, Harris WS, Kris-Etherton PM. Omega-3 fatty acids in food and pharma: the enabling role of
biotechnology. Curr Atheroscler Rep [Internet]. 2011 Dec;13(6):467–73. Available from:
http://dx.doi.org/10.1007/s11883-011-0206-z
2. Ashwin KS, Muralidharan NP. Vancomycin-resistant enterococcus (VRE) vs Methicillin-resistant
Staphylococcus Aureus (MRSA). Indian J Med Microbiol [Internet]. 2015 Feb;33 Suppl:166–7. Available
from: http://dx.doi.org/10.4103/0255-0857.150976
3. Baum SJ, Kris-Etherton PM, Willett WC, Lichtenstein AH, Rudel LL, Maki KC, et al. Fatty acids in
cardiovascular health and disease: a comprehensive update. J Clin Lipidol [Internet]. 2012 May;6(3):216–
34. Available from: http://dx.doi.org/10.1016/j.jacl.2012.04.077
4. Girija ASS, Smiline Girija AS, Vijayashree Priyadharsini J, Paramasivam A. Plasmid-encoded resistance to
trimethoprim/sulfamethoxazole mediated by dfrA1, dfrA5, sul1 and sul2 among Acinetobacter baumannii
isolated from urine samples of patients with severe urinary tract infection [Internet]. Vol. 17, Journal of
Global Antimicrobial Resistance. 2019. p. 145–6. Available from:
http://dx.doi.org/10.1016/j.jgar.2019.04.001
5. Harris WS. The omega-3 index: clinical utility for therapeutic intervention. Curr Cardiol Rep [Internet].
2010 Nov;12(6):503–8. Available from: http://dx.doi.org/10.1007/s11886-010-0141-6
6. Selvakumar R, Np M. COMPARISON IN BENEFITS OF HERBAL MOUTHWASHES WITH
CHLORHEXIDINE MOUTHWASH: A REVIEW [Internet]. Vol. 10, Asian Journal of Pharmaceutical
and Clinical Research. 2017. p. 3. Available from: http://dx.doi.org/10.22159/ajpcr.2017.v10i2.13304
7. Burdge G. α-Linolenic acid metabolism in men and women: nutritional and biological implications.
CurrOpin Clin NutrMetab Care [Internet]. 2004 Mar [cited 2020 Jun 2];7(2):137.
8. Shahana RY, Muralidharan NP. Efficacy of mouth rinse in maintaining oral health of patients attending
orthodontic clinics [Internet]. Vol. 9, Research Journal of Pharmacy and Technology. 2016. p. 1991.
Available from: http://dx.doi.org/10.5958/0974-360x.2016.00406.6
9. Marickar RF, Geetha RV, Neelakantan P. Efficacy of contemporary and novel Intracanal medicaments
against enterococcus faecalis. J Clin Pediatr Dent [Internet]. 2014 Autumn;39(1):47–50. Available from:
http://dx.doi.org/10.17796/jcpd.39.1.wmw9768314h56666
10. Pawlosky RJ, Hibbeln JR, Novotny JA, Salem N Jr. Physiological compartmental analysis of alphalinolenic acid metabolism in adult humans. J Lipid Res [Internet]. 2001 Aug;42(8):1257–65.
11. Wall R, Ross RP, Fitzgerald GF, Stanton C. Fatty acids from fish: the anti-inflammatory potential of longchain omega-3 fatty acids. Nutr Rev [Internet]. 2010 May;68(5):280–9. Available from:
http://dx.doi.org/10.1111/j.1753-4887.2010.00287.x
12. DeFilippis AP, Sperling LS. Understanding omega-3’s [Internet]. Vol. 151, American Heart Journal. 2006.
p. 564–70. Available from: http://dx.doi.org/10.1016/j.ahj.2005.03.051
13. Adarme-Vega TC, Lim DKY, Timmins M, Vernen F, Li Y, Schenk PM. Microalgal biofactories: a
promising approach towards sustainable omega-3 fatty acid production. Microb Cell Fact [Internet]. 2012
Jul 25;11:96. Available from: http://dx.doi.org/10.1186/1475-2859-11-96
14. Mickleborough TD, Sinex JA, Platt D, Chapman RF, Hirt M. The effects PCSO-524®, a patented marine
oil lipid and omega-3 PUFA blend derived from the New Zealand green lipped mussel (Perna canaliculus),
on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men:
a randomized, placebo controlled trial. J Int Soc Sports Nutr [Internet]. 2015 Feb 19;12:10. Available from:
http://dx.doi.org/10.1186/s12970-015-0073-z
15. Peoples GE, McLennan PL. Dietary fish oil reduces skeletal muscle oxygen consumption, provides fatigue
resistance and improves contractile recovery in the rat in vivo hindlimb. Br J Nutr [Internet]. 2010
Dec;104(12):1771–9. Available from: http://dx.doi.org/10.1017/S0007114510002928
16. Jones PJH, Senanayake VK, Pu S, Jenkins DJA, Connelly PW, Lamarche B, et al. DHA-enriched higholeic acid canola oil improves lipid profile and lowers predicted cardiovascular disease risk in the canola
oil multicenter randomized controlled trial. Am J Clin Nutr [Internet]. 2014 Jul;100(1):88–97. Available
from: http://dx.doi.org/10.3945/ajcn.113.081133
17. Devassy JG, Leng S, Gabbs M, Monirujjaman M, Aukema HM. Omega-3 Polyunsaturated Fatty Acids and
Oxylipins in Neuroinflammation and Management of Alzheimer Disease. Adv Nutr [Internet]. 2016
Sep;7(5):905–16. Available from: http://dx.doi.org/10.3945/an.116.012187
18. Van Elswyk ME, McNeill SH. Impact of grass/forage feeding versus grain finishing on beef nutrients and
sensory quality: the U.S. experience. Meat Sci [Internet]. 2014 Jan;96(1):535–40. Available from:
http://dx.doi.org/10.1016/j.meatsci.2013.08.010
19. Pratha AA, Ashwatha Pratha A, Geetha RV. Awareness on Hepatitis-B vaccination among dental studentsA Questionnaire Survey [Internet]. Vol. 10, Research Journal of Pharmacy and Technology. 2017. p. 1360.
Available from: http://dx.doi.org/10.5958/0974-360x.2017.00240.2
20. Siscovick DS. Dietary Intake and Cell Membrane Levels of Long-Chain n-3 Polyunsaturated Fatty Acids
and the Risk of Primary Cardiac Arrest [Internet]. Vol. 274, JAMA: The Journal of the American Medical
Association. 1995. p. 1363. Available from: http://dx.doi.org/10.1001/jama.1995.03530170043030
21. Indian Council of Medical Research. Expert Group. Nutrient Requirements and Recommended Dietary
Allowances for Indians: A Report of the Expert Group of the Indian Council of Medical Research
[Internet]. Indian Council of Medical Research; 2010. 255 p.
22. Dwarkanath P, Muthayya S, Thomas T, Vaz M, Parikh P, Mehra R, et al. Polyunsaturated fatty acid
consumption and concentration among South Indian women during pregnancy. Asia Pac J Clin Nutr
[Internet]. 2009;18(3):389–94. Available from: https://www.ncbi.nlm.nih.gov/pubmed/19786387
23. Sharma K. Burden of non communicable diseases in India: Setting priority for action [Internet]. Vol. 2,
International Journal of Medical Science and Public Health. 2013. p. 7. Available from:
http://dx.doi.org/10.5455/ijmsph.2013.2.7-11
24. Vaishali M, Geetha RV. Antibacterial activity of Orange peel oil on Streptococcus mutans and
Enterococcus-An In-vitro study [Internet]. Vol. 11, Research Journal of Pharmacy and Technology. 2018.
p. 513. Available from: http://dx.doi.org/10.5958/0974-360x.2018.00094.x
25. SanGiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and
disease of the retina [Internet]. Vol. 24, Progress in Retinal and Eye Research. 2005. p. 87–138. Available
from: http://dx.doi.org/10.1016/j.preteyeres.2004.06.002
26. Fritsche KL. Too much linoleic acid promotes inflammation—doesn’t it? [Internet]. Vol. 79,
Prostaglandins, Leukotrienes and Essential Fatty Acids. 2008. p. 173–5. Available from:
http://dx.doi.org/10.1016/j.plefa.2008.09.019
27. Das UN. Essential fatty acids: biochemistry, physiology and pathology [Internet]. Vol. 1, Biotechnology
Journal. 2006. p. 420–39. Available from: http://dx.doi.org/10.1002/biot.200600012
28. Dunstan JA, Mitoulas LR, Dixon G, Doherty DA, Hartmann PE, Simmer K, et al. The Effects of Fish Oil
Supplementation in Pregnancy on Breast Milk Fatty Acid Composition Over the Course of Lactation: A
Randomized Controlled Trial [Internet]. Vol. 62, Pediatric Research. 2007. p. 689–94. Available from:
http://dx.doi.org/10.1203/pdr.0b013e318159a93a
29. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution
lipid mediators [Internet]. Vol. 8, Nature Reviews Immunology. 2008. p. 349–61. Available from:
http://dx.doi.org/10.1038/nri2294
30. Neff LM, Culiner J, Cunningham‐Rundles S, Seidman C, Meehan D, Maturi J, et al. Algal
Docosahexaenoic Acid Affects Plasma Lipoprotein Particle Size Distribution in Overweight and Obese
Adults [Internet]. Vol. 141, The Journal of Nutrition. 2011. p. 207–13. Available from:
http://dx.doi.org/10.3945/jn.110.130021
31. Brasky TM, Till C, White E, Neuhouser ML, Song X, Goodman P, et al. Serum Phospholipid Fatty Acids
and Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial [Internet]. Vol. 173,
American Journal of Epidemiology. 2011. p. 1429–39. Available from:
http://dx.doi.org/10.1093/aje/kwr027
32. Brasky TM, Darke AK, Song X, Tangen CM, Goodman PJ, Thompson IM, et al. Plasma phospholipid fatty
acids and prostate cancer risk in the SELECT trial. J Natl Cancer Inst [Internet]. 2013 Aug
7;105(15):1132–41. Available from: http://dx.doi.org/10.1093/jnci/djt174
33. Abbott SK, Else PL, Atkins TA, Hulbert AJ. Fatty acid composition of membrane bilayers: importance of
diet polyunsaturated fat balance. Biochim Biophys Acta [Internet]. 2012 May;1818(5):1309–17. Available
from: http://dx.doi.org/10.1016/j.bbamem.2012.01.011
34. M MA, Geetha RV, Thangavelu L. Evaluation oEvaluation of anti-inflammatory action of Laurus nobilisan in vitro study of anti-inflammatory action of Laurus nobilis-an in vitro study [Internet]. Vol. 10,
International Journal of Research in Pharmaceutical Sciences. 2019. p. 1209–13. Available from:
http://dx.doi.org/10.26452/ijrps.v10i2.408
35. Girija As S, Priyadharsini J V. CLSI based antibiogram profile and the deitection of MDR and XDR strains
of Acinetobacter baumannii isolated from urine samples. Med J Islam Repub Iran [Internet]. 2019 Feb
8;33:3. Available from: http://dx.doi.org/10.34171/mjiri.33.3
36. Ibarguren M, López DJ, Escribá PV. The effect of natural and synthetic fatty acids on membrane structure,
microdomain organization, cellular functions and human health [Internet]. Vol. 1838, Biochimica et
Biophysica Acta (BBA) - Biomembranes. 2014. p. 1518–28. Available from:
http://dx.doi.org/10.1016/j.bbamem.2013.12.021
37. Bäck M. Omega-3 fatty acids in atherosclerosis and coronary artery disease [Internet]. Vol. 3, Future
Science OA. 2017. p. FSO236. Available from: http://dx.doi.org/10.4155/fsoa-2017-0067
38. Van Noolen L, Bäck M, Arnaud C, Rey A, Petri MH, Levy P, et al. Docosahexaenoic acid supplementation
modifies fatty acid incorporation in tissues and prevents hypoxia induced-atherosclerosis progression in
apolipoprotein-E deficient mice. Prostaglandins Leukot Essent Fatty Acids [Internet]. 2014 Oct;91(4):111–
7. Available from: http://dx.doi.org/10.1016/j.plefa.2014.07.016
39. Salic K, Morrison MC, Verschuren L, Wielinga PY, Wu L, Kleemann R, et al. Resolvin E1 attenuates
atherosclerosis in absence of cholesterol-lowering effects and on top of atorvastatin [Internet]. Vol. 250,
Atherosclerosis. 2016. p. 158–65. Available from: http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.001
40. Girija SAS, Jayaseelan VP, Arumugam P. Prevalence of VIM- and GIM-producing Acinetobacter
baumannii from patients with severe urinary tract infection [Internet]. Vol. 65, Acta Microbiologica et
Immunologica Hungarica. 2018. p. 539–50. Available from: http://dx.doi.org/10.1556/030.65.2018.038
41. Johnson JL, Newby AC. Macrophage heterogeneity in atherosclerotic plaques [Internet]. Vol. 20, Current
Opinion in Lipidology. 2009. p. 370–8. Available from: http://dx.doi.org/10.1097/mol.0b013e3283309848
42. Ajith TA, Jayakumar TG. Omega-3 fatty acids in coronary heart disease: Recent updates and future
perspectives. Clin Exp Pharmacol Physiol [Internet]. 2019 Jan;46(1):11–8. Available from:
http://dx.doi.org/10.1111/1440-1681.13034
43. Bäck M, Hansson GK. Anti-inflammatory therapies for atherosclerosis. Nat Rev Cardiol [Internet]. 2015
Apr;12(4):199–211. Available from: http://dx.doi.org/10.1038/nrcardio.2015.5
44. Del Gobbo LC, Imamura F, Aslibekyan S, Marklund M, Virtanen JK, Wennberg M, et al. ω-3
Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies.
JAMA Intern Med [Internet]. 2016 Aug 1;176(8):1155–66. Available from:
http://dx.doi.org/10.1001/jamainternmed.2016.2925
45. Kromhout D. Omega-3 fatty acids and coronary heart disease. The final verdict? [Internet]. Vol. 23,
Current Opinion in Lipidology. 2012. p. 554–9. Available from:
http://dx.doi.org/10.1097/mol.0b013e328359515f
46. Parkinson AJ, Cruz AL, Heyward WL, Bulkow LR, Hall D, Barstaed L, et al. Elevated concentrations of
plasma ω-3 polyunsaturated fatty acids among Alaskan Eskimos [Internet]. Vol. 59, The American Journal
of Clinical Nutrition. 1994. p. 384–8. Available from: http://dx.doi.org/10.1093/ajcn/59.2.384
47. Djoussé L, Akinkuolie AO, Wu JHY, Ding EL, Gaziano JM. Fish consumption, omega-3 fatty acids and
risk of heart failure: a meta-analysis. Clin Nutr [Internet]. 2012 Dec;31(6):846–53. Available from:
http://dx.doi.org/10.1016/j.clnu.2012.05.010
48. Kris-Etherton PM, Harris WS, Appel LJ. Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and
Cardiovascular Disease [Internet]. Vol. 23, Arteriosclerosis, Thrombosis, and Vascular Biology. 2003.
Available from: http://dx.doi.org/10.1161/01.atv.0000038493.65177.94
49. Smiline A, Vijayashree JP, Paramasivam A. Molecular characterization of plasmid-encoded blaTEM,
blaSHV and blaCTX-M among extended spectrum β-lactamases [ESBLs] producing Acinetobacter
baumannii. Br J Biomed Sci [Internet]. 2018 Oct;75(4):200–2. Available from:
http://dx.doi.org/10.1080/09674845.2018.1492207
50. Paramasivam A, Vijayashree Priyadharsini J, Raghunandhakumar S. N6-adenosine methylation (m6A): a
promising new molecular target in hypertension and cardiovascular diseases. Hypertens Res [Internet].
2020 Feb;43(2):153–4. Available from: http://dx.doi.org/10.1038/s41440-019-0338-z
51. Maroon JC, Bost JW. ω-3 Fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal antiinflammatory drugs for discogenic pain [Internet]. Vol. 65, Surgical Neurology. 2006. p. 326–31. Available
from: http://dx.doi.org/10.1016/j.surneu.2005.10.023
52. Calder PC. Omega-3 fatty acids and inflammatory processes. Nutrients [Internet]. 2010 Mar;2(3):355–74.
Available from: http://dx.doi.org/10.3390/nu2030355
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