AWARENESS OF VINCA ALKALOIDS AMONG DENTAL STUDENTS
DOI:
https://doi.org/10.61841/n7mbbv05Keywords:
Awareness,vincaalkaloids, dental studentsAbstract
Vincristine along with vinblastine are dual indole-based conjugated Vinca alkaloids formed from foliage of the herb Catharanthusroseus, traditionally known as Vincarosea vincristine , that have been effectively prescribed as single treatment and also in conjunction with other medications in hematological and stable malignancies chemotherapy for tumors. The purpose of this survey was to assess awareness of medical use of vinca alkaloids among dental undergraduate students. A cross-section study was performed with a self-directed survey questionnaire containing 10 queries distributed among 100 dental students. The questionnaire assessed the awareness about vinca alkaloids, their medicinal uses, anticancer activity, mechanism of action and side effects. The responses were recorded and analysed.94% of the respondents were not aware of medical uses of vinca alkaloids.95% were not aware of anticancer activity of vinca alkaloids.97 % were not aware of the mechanisms of action of vinca alkaloids. Again 97% were not aware of side effects of the vinca alkaloids. This study concluded the awareness about the medical use of vinca alkaloids among dental students was poor. Majority of them are not aware of the anticancer activity of vinca alkaloids.
Downloads
References
1. Einhorn, L. H. (1977). Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination
Chemotherapy in Disseminated Testicular Cancer. In Annals of Internal Medicine (Vol. 87, Issue 3, p.
293). https://doi.org/10.7326/0003-4819-87-3-293
2. Gigant, B., Wang, C., Ravelli, R. B. G., Roussi, F., Steinmetz, M. O., Curmi, P. A., Sobel, A., &Knossow,
M. (2005). Structural basis for the regulation of tubulin by vinblastine. Nature, 435(7041), 519–522.
3. Keglevich, P., Hazai, L., Kalaus, G., &Szántay, C. (2012). Modifications on the basic skeletons of
vinblastine and vincristine. Molecules , 17(5), 5893–5914.
4. Marantz, R., Ventilla, M., & Shelanski, M. (1969). Vinblastine-Induced Precipitation of Microtubule
Protein. In Science (Vol. 165, Issue 3892, pp. 498–499). https://doi.org/10.1126/science.165.3892.498
5. Owellen, R. J., Owens, A. H., & Donigian, D. W. (1972). The binding of vincristine, vinblastine and
colchicine to tubulin. In Biochemical and Biophysical Research Communications (Vol. 47, Issue 4, pp.
685–691). https://doi.org/10.1016/0006-291x(72)90546-3
6. Rao, K. S. P. B., Bhushana, K. S., Collard, M. P. M., Dejonghe, J. P. C., Atassi, G., Hannart, J. A., &
Trouet, A. (1985). Vinblastin-23-oyl amino acid derivatives: chemistry, physicochemical data, toxicity,
and antitumor activities against P388 and L1210 leukemias. In Journal of Medicinal Chemistry (Vol. 28,
Issue 8, pp. 1079–1088). https://doi.org/10.1021/jm00146a017
7. Venghateri, J. B., Gupta, T. K., Verma, P. J., Kunwar, A., & Panda, D. (2013). Ansamitocin P3
Depolymerizes Microtubules and Induces Apoptosis by Binding to Tubulin at the Vinblastine Site. In
PLoS ONE (Vol. 8, Issue 10, p. e75182). https://doi.org/10.1371/journal.pone.0075182
8. Williams, S. D., Birch, R., Einhorn, L. H., Irwin, L., Greco, F. A.,&Loehrer, P. J. (1987). Treatment of
disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. The New
England Journal of Medicine, 316(23), 1435–1440.
9. Wilson, L., Bryan, J., Ruby, A., & Mazia, D. (1970). Precipitation of Proteins by Vinblastine and Calcium
Ions. In Proceedings of the National Academy of Sciences (Vol. 66, Issue 3, pp. 807–814).
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.