AWARENESS OF VINCA ALKALOIDS AMONG DENTAL STUDENTS

Authors

  • Nithyanandham Masilamani Tutor, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai,India. Author
  • Dhanraj Ganapathy Professor &Head of Department, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, India. Author

DOI:

https://doi.org/10.61841/n7mbbv05

Keywords:

Awareness,vincaalkaloids, dental students

Abstract

 Vincristine along with vinblastine are dual indole-based conjugated Vinca alkaloids formed from foliage of the herb Catharanthusroseus, traditionally known as Vincarosea vincristine , that have been effectively prescribed as single treatment and also in conjunction with other medications in hematological and stable malignancies chemotherapy for tumors. The purpose of this survey was to assess awareness of medical use of vinca alkaloids among dental undergraduate students. A cross-section study was performed with a self-directed survey questionnaire containing 10 queries distributed among 100 dental students. The questionnaire assessed the awareness about vinca alkaloids, their medicinal uses, anticancer activity, mechanism of action and side effects. The responses were recorded and analysed.94% of the respondents were not aware of medical uses of vinca alkaloids.95% were not aware of anticancer activity of vinca alkaloids.97 % were not aware of the mechanisms of action of vinca alkaloids. Again 97% were not aware of side effects of the vinca alkaloids. This study concluded the awareness about the medical use of vinca alkaloids among dental students was poor. Majority of them are not aware of the anticancer activity of vinca alkaloids. 

Downloads

Download data is not yet available.

References

1. Einhorn, L. H. (1977). Cis-Diamminedichloroplatinum, Vinblastine, and Bleomycin Combination

Chemotherapy in Disseminated Testicular Cancer. In Annals of Internal Medicine (Vol. 87, Issue 3, p.

293). https://doi.org/10.7326/0003-4819-87-3-293

2. Gigant, B., Wang, C., Ravelli, R. B. G., Roussi, F., Steinmetz, M. O., Curmi, P. A., Sobel, A., &Knossow,

M. (2005). Structural basis for the regulation of tubulin by vinblastine. Nature, 435(7041), 519–522.

3. Keglevich, P., Hazai, L., Kalaus, G., &Szántay, C. (2012). Modifications on the basic skeletons of

vinblastine and vincristine. Molecules , 17(5), 5893–5914.

4. Marantz, R., Ventilla, M., & Shelanski, M. (1969). Vinblastine-Induced Precipitation of Microtubule

Protein. In Science (Vol. 165, Issue 3892, pp. 498–499). https://doi.org/10.1126/science.165.3892.498

5. Owellen, R. J., Owens, A. H., & Donigian, D. W. (1972). The binding of vincristine, vinblastine and

colchicine to tubulin. In Biochemical and Biophysical Research Communications (Vol. 47, Issue 4, pp.

685–691). https://doi.org/10.1016/0006-291x(72)90546-3

6. Rao, K. S. P. B., Bhushana, K. S., Collard, M. P. M., Dejonghe, J. P. C., Atassi, G., Hannart, J. A., &

Trouet, A. (1985). Vinblastin-23-oyl amino acid derivatives: chemistry, physicochemical data, toxicity,

and antitumor activities against P388 and L1210 leukemias. In Journal of Medicinal Chemistry (Vol. 28,

Issue 8, pp. 1079–1088). https://doi.org/10.1021/jm00146a017

7. Venghateri, J. B., Gupta, T. K., Verma, P. J., Kunwar, A., & Panda, D. (2013). Ansamitocin P3

Depolymerizes Microtubules and Induces Apoptosis by Binding to Tubulin at the Vinblastine Site. In

PLoS ONE (Vol. 8, Issue 10, p. e75182). https://doi.org/10.1371/journal.pone.0075182

8. Williams, S. D., Birch, R., Einhorn, L. H., Irwin, L., Greco, F. A.,&Loehrer, P. J. (1987). Treatment of

disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. The New

England Journal of Medicine, 316(23), 1435–1440.

9. Wilson, L., Bryan, J., Ruby, A., & Mazia, D. (1970). Precipitation of Proteins by Vinblastine and Calcium

Ions. In Proceedings of the National Academy of Sciences (Vol. 66, Issue 3, pp. 807–814).

https://doi.org/10.1073/pnas.66.3.807

Downloads

Published

14.04.2025

How to Cite

Masilamani, N., & Ganapathy, D. (2025). AWARENESS OF VINCA ALKALOIDS AMONG DENTAL STUDENTS. International Journal of Psychosocial Rehabilitation, 23(5), 996-1000. https://doi.org/10.61841/n7mbbv05